HLA Class II

 

 

High-resolution HLA Class II typing:

Taking advantage from the precise and high-resolution molecular method of PCR-RDB for HLA class II typing . All HLA DRB1, DRB3, DRB4, DRB5, DQB1 and  DQA1 genes typed at high-resolution level. For example, in the DRB region more than 160 alleles are specified for DRB1, DRB3, DRB4 and DRB5 genes. Following multiplex PCR of the DNA for the four DRB genes, the PCR products are hybridized with the sequence-specific probes and the results are analyzed using a computer program and the individuals’ genotypes are determined. Furthermore intermediate resolution typing of HLA class I genes are also performed

Indications and benefits

HLA typing has got a lot of applications including;

Bone marrow and organ transplantation,

paternity analysis and other forensic issues as an alternative to the DNA fingerprinting.

Disease association such as Celiac Disease

Contact us: Tel:(+98 21)88003811-12

High resolution HLA class II typing kits

Recently some kit for genotyping HLA class II has been developed (Invention number: 28495) that have a high resolution power. It specifies over 160 alleles for DRB1, DRB3, DRB4, and DRB5; While the other available kits in Iran recognize just 24 alleles and the rest remain undetected. The kit is now available. Each kit is used for 20 individuals. Training and computer program for analysis are offered for free. Contact us for more information on the kit and other services we offer: The address