مسئول فني آزمايشگاه ژنتيك پزشكي دكتر زماني

 

دکتر مهدي زماني

 متخصص ژنتيك پزشكي Ph.D. از دانشگاه لوون بلژيك

فوق دكتراي تخصصي بيماريهاي ژنتيكي و تعيين ريسك از بلژيك

عضو هيئت علمي دانشکده پزشکي  دانشگاه علوم پزشكي تهران

 عضو آكادمي علوم نيويورك , عضو جامعه تحقيقات ديابت اروپا EASD

نماينده ايران در شبكه Thematic بيماري CF جامعه اروپا

 

مقالات چاپ شده در ژورنالهاي علمي بين المللي

 

·        Author of publications in international Journals

 

1.      Zamani M, Buyse I, Legius E, Decorte R, Marynen P, Bouillon R and Cassiman JJ (1994): Possible association of CD3 and CD4 Polymorphisms with IDDM.  Clin. Exp. Immunology 97:517-521

2.      Zamani M, Spaepen M, Buyse I, Marynen P, Bex M, Bouillon R and  Cassiman JJ (1994): Improved risk assessment for IDDM by analysis of amino acids in HLA- DQ and DRB1 loci. Eur J Human Genetics 2:177-184

3.      Zamani M, De Hert M, Spaepen M, Hermans M, Marynen P, Cassiman JJ and Peuskens J (1994): Study of the possible association of HLA class II, CD4 and CD3 polymorphisms with schizophrenia. Am J Medical Genetics. 54:372-377

4.      Buyse I, Sandkuyl LA, Zamani M, Gu XX, Bouillon R, BeX M, Dooms L, Emonds MP, Duhamel M, Marynen P and Cassiman JJ (1994): Association of particular HLA class II alleles, haplotypes, and genotypes with susceptibility to insulin dependent diabetes mellitus in the Belgian population. Diabetologia 37:808-817

5.      Decorte R, Buyse I, Zamani M, Gu XX, Spaepen M, Marynen P, De Canck l, Emonds M and  Cassiman JJ (1994): Distribution of HLA Class II genes in a Caucasian population as determined by PCR and reversed-dot-blot typing. Adv. Forensic Haemogenet. 5:490-492

6.      Vandevyver C, Buyse I, Philippaerts L, Zamani M, Medaer R, Carton H, Cassiman JJ and Raus J (1994): HLA and T-cell receptor polymorphisms in Belgian multiple sclerosis patients. J of Neuroimmonology 52:25-32

7.      Zamani M , Spaepen M, Buyse I, Legius E, Decorte R, Bex M, Marynen P, Bouillon R and  Cassiman JJ (1995): Increased and decreased relative risk for Non- insulin-dependent diabetes mellitus conferred by HLA class II and by CD4 alleles. Clinical Genetics 47:225-230.

8.      Zamani M, Gu XX, Spaepen M, Vandevyver C, Raus J, Marynen P, Carton H and Cassiman JJ (1995): Importance of HLA-DRB1 and DQA1 genes and of the amino acid polymorphisms in the functional domain of DRB1 chain in Multiple Sclerosis. J of Neuroimmonology 59:77-82.

9.      Zamani M, Pociot F, Raeymaekers P, Nerup J and Cassiman JJ (1996): Linkage of type I diabetes to 15q26 (IDDM3) in Danish population. Human Genet 98:491-496

10.  Zamani M, Pociot F, Spaepen M, Raeymaekers P, Nerup J and Cassiman JJ (1996): Linkage and association of the HLA gene complex with IDDM in Danish families: Strong linkage between DRb1Lys71+ and IDDM. J Medical Genetics 33:899-905

11.  Zamani M and Cassiman JJ. (1998) : Reevaluation of the importance of polymorphic HLA class II alleles and amino acids in the susceptibility of individuals to type I Diabetes in different populations. Am J Medical Genetics 76:183-194

12.  Kiristiansen OP, Zamani M, Johannesen J, Mandrup-Poulsen T, Cassiman JJ,  Nerup J, Pociot F, DIEGG and DSGD(1998): Linkage between a CD4 gene polymorphism and IDDM in Danish IDDM patients. Diabetes 47:281-283

13.  Pandey J, Zamani M and Cassiman JJ. (1999) : Epistatic effects of genes encoding tumor necrosis factor a, immunoglobulin allotypes, and HLA antigens on susceptibility to non-insulin dependent (type 2) diabetes. Immunogenetics 49:860-864

14.  Zamani M , Spaepen M, Bex M, , Bouillon R and  Cassiman JJ (2000): Primary role of the  HLA class II DRB1*0301 allele in Graves' Disease. Am J Medical Genetics: 95:432-437

15.  Zamani M , Huang C, Spaepen M and Cassiman JJ and (2001): Linkage and association of the HLA class II genes with vitiligo in Dutch families. British j of Dermatology 144:90-94

16.  Rahmani S.A., Mohadess S.M., Aghazadeh A, Jahani M, Izadyar M, Zamani M and Mehdipour P. (2006): Investigation of TEL/AML1 and BCR/ABL fusion genes in patients affected by acute lymphoblastic leukaemia using interphase in situ hybridization. Journal of Sciences, .I.R. of Iran 17:17-25

17.  Behjati F, Atri m, Najmabadi H, Nouri K, Zamani M and Mehdipour P (2006): Prognostic value of chromosome 1 and 8 copy number in invasive Ductal breast carcinoma among Iranian women: An interphase FISH analysis. Pathology Oncology Research 11:157-163

18.  Alibahksh R. and  Zamani M. (2006) Mutation analysis of CFTR gene in 70 Iranian pationts by ARMS-PCR. Iranian J Allergy, Asthma and Immunology  5:3-8

19.  Zamani M, Pociot F, Michelsen B, Rambrat T, Nerup J and Cassiman JJ. (2006): Improved prediction of risk for and monitoring of type I diabetes by testing for DR1Lys71+/+ genotype and  GAD65 autoantibody. Am J Medical Genetics: submitted

20.  Reza Alibakhshi1,2, Harry Cuppens3, Roya Kianishirazi1, Jean-Jacques Cassiman3 and Mahdi Zamani1:  Global analysis of the CFTR gene mutations in Iranian Cystic fibrosis patients: identification of nine novel mutations 2006 Journal of CF : submitted

 

كتابها:

1-Huang C, Spaepen M, Zamani M,  Buyse I, Gu XX, Bouillon R, and  Cassiman JJ (1997): Belgium: Insulin-dependent diabetes mellitus. pp 373

Non insulin-dependent diabetes mellitus. pp 394

Belgium: Multiple Sclerosis. PP 391

Belgium: Schizophrenia. pp 415

BooK; HLA 1997, Published by UCLA Tissue Typing Laboratory USA.

 

2- مهدي زماني، تازه هاي طب مادر و جنين, فصل اول ؛ اصول ژنتيك پزشكي، ناشر معاونت پژوهشي دانشگاه علوم پزشكي تهران، 1378.

 

3 - مهدي زماني, ژنتيك بيماريها,  فصل اول ؛ ژنتيك پزشكي, فصل  نهم؛ تشحيص مولكولي  بيماريهاي ژنتيكي قبل و بعد از تولد, ناشر معاونت پژوهشي دانشگاه علوم پزشكي تهران,(ISBN:964-7445-76-8) 1383

 

4- مهدي زماني, بيماريهاي عضلاني فصل ششم: ژنتيک بيماريهاي عضلاني ناشر معاونت پژوهشي دانشگاه علوم پزشكي تهران,(ISBN:964-7445-47-4) 1384

 

 

 

 

مقاله در مجله داخلي:

 

1-مهدي زماني , جان نيروپ , ژونژاك كاسيمان:  پيوستگي وارتباط كمپلكس ژنهاي HLA  با بيماري ديابت قندي نوع1 در 81  خانواده : پيوستگي شديد ژن DRB1Lys71+ با ديابت نوع 1  مجله ديابت و ليپيد ايران 1381 شماره 1: 51-41

2-مهدي زماني: قدرت و دقت تشخيص روش PCR-Reverse Dot- Blot در تعيين ژنوتيپهاي ژنهايHLA-Class II   در پيوند ومقايسه آن با روشهاي ديگر HLA typing . مجله دانشكده پزشكي دانشگاه علوم پزشكي تهران, 1383, سال 62 , شماره 12: 978-974

 

3-مهدي زماني, محمد امين طباطبايي فر, آرزو صوابي اصفهاني, فريدون مصطفوي, آرياستوده, باقر لاريجاني: پيوستگي  بين چند شكلي ژن CD4 با ديابت نوع 1 (IDDM) در جمعيت ايراني جله ديابت و ليپيد ايران 1384 دوره 4 شماره 4: 9-1

 

4-  مهدي زماني, اردشير قوام زاده : ارتباط احتمالي الل خاصي از HLA-DRB1  درافزايش خطر رد پيوند سلولهاي بنيادي هماتوپوئتيک بين خواهر و برادرهاي که HLA يکسان دارند (خرداد 1385 به مجله دانشکده پزشکي ارائه شده)

 

خلاصه مقالات

 

Abstracts

 

1.      Zamani Ghabanbasani M, Gu XX, Buyse I, Spaepen M, Marynen P, Decorte R, Amery A, Raus J and Cassiman JJ: Distribution of HLA class II alleles in Multiple Sclerosis and Hypertension.  European Society of Human Genetics, 25th Annual Meeting, May 6-9, 1993, Barcelona, Spain. Abstract no:245

2.      De Hert M, Zamani Ghabanbasani M, Hermans M, Cassiman JJ and Peuskens J: Frequency of HLA class II alleles and CD4 alleles in schizophrenia (1993). Abstract of the 1993 World Congress on Psychiatric Genetics, New Orleans, USA, October 2-5, 1993. Psychiatric Genet. 3, A85

3.      Vandevyver C, Buyse I, Philippaerts L, Zamani Ghabanbasani M, Medaer R, Carton H, Cassiman J.J and Raus J: HLA and T-cell receptor polymorphisms in Belgian multiple sclerosis patients. First forum of Young European Researcher: Molecular Mechanisms of Central Immune Self-Tolerance. July 18-23, 1993

4.      Decorte R, Buyse I, Zamani M, Gu XX, Spaepen M, Marynen P, De Canck l, Emonds M and  Cassiman JJ (1993): Distribution of HLA Class II genes in a Caucasian population as determined by PCR and reversed-dot-blot typing. 15th Inrern. Congress International Society of Forensic Haemogenetics 13-15 October 1993 - Venice, Italy.

5.      Zamani Ghabanbasani M, Spaepen M, Bouillon R and  Cassiman JJ: Association of HLA class II, CD3 and CD4 with NIDDM in a belgian population. 8th European Histocompatibility Conference-March 7-9 1994. Abstract no:191

6.      De Hert M, Zamani Ghabanbasani M, Cassiman JJ and Peuskens J: Frequency of HLA class II alleles and CD4 alleles in schizophrenia (1994). Winter Workshop on Schizophrenia Research. Schizophrenia Research 11:126

7.      Zamani Ghabanbasani M, Spaepen M and Cassiman JJ (1994): Association of amino acids encoded by polymorphic HLA-DQ/DRB loci with IDDM. 26th Annual Meeting of the European Society of Human Genetics, June 1-5, 1994 - Paris, France. Abstract no:371

8.      Kristiansen OP, Pociot F, Zamani Ghabanbasani M, Johannesen J, Cassiman JJ, Nerup J and DSGD (1995): Study of association between and linkage of a CD4 gene polymorphism and IDDM in the Danish population. The 31st annual meeting of the European Association for the Study of Diabetes (EASD). Diabetologia 38:A29   

9.      Zamani Ghabanbasani, F. Pociot, M. Spaepen, P. Raeymaekers, J. Nerup and J.-J. Cassiman (1995): Linkage of HLA-DQ and DRB1 genes with IDDM in Danish population. American society of human genetics - 45th Annual Meeting - Minneapolis, October 24-28, 1995, USA. Am. J. Human Genet ; 57:suppl A213

10.  Kristiansen OP, Pociot F, Zamani Ghabanbasani M, Johannesen J, Cassiman JJ, Nerup J and DSGD (1995): CD4 gene polymorphism and IDDM: Studies of linkage and association in the Danish population. Immunology of Diabetes Society, 1st Congress / 14th Immunology of Diabetes Workshop Meeting : 31 October - 2 November, Orvieto : Abstract  

11.  Zamani R. Vlietinck and J.-J. Cassiman (1996): Role of amino acides located in the antigen binding groove of HLA class II molecules in the risk for IDDM. The 32nd annual meeting of the EASD, Vienna, Austria. Diabetologia 39:Suppl. 1 A80

12.  Pociot F, Zamani M, Raeymaekers P, Nerup J and Cassiman JJ (1996): Linkage of type 1 diabetes to 15q26 (IDDM3) in the Danish population. Diabetologia 39:Suppl. 1 A62 (Abstract)

13.  Zamani and J.-J. Cassiman (1996): Modification of the calculation of the predictive values of genetic tests as a tool to score their clinical relevance. American society of human genetics - 46th Annual Meeting- San Francisco, October 29-November 2 USA. Am. J. Human Genet ; 59:suppl. A194

14.  Zamani M, Pociot F,  Nerup J and Cassiman JJ. (1999): Improved risk prediction for IDDM  by testing for the combined presence of HLA-DR1Lys71+/+ genotype and GAA and ICA512/IA-2 (ICA) autoantibodies. Diabetologia 42: suppl. 1 A93

15.   Zamani M , Huang C, Spaepen M and Cassiman JJ and (2001): Linkage and association of the HLA class II genes with vitiligo in Dutch families. European journal of Human Genetics 9: suppl. A1309

16.   Mosaiebi S, Zamani M. Possible association of CD4 with vitiligo in Iran.  Internasional Genetic Congress, Dubai, 2003

17.   Alibakhsh R and Zamani M. Molecular analysis of CFTR gene mutation in Iranian CF patients. European journal of Human Genetics 12: suppl. P0726, 2004

18.   Zamani M. Tabatabai M. A., Mashaghi   A. R. and  Mosaiebi S.  Possible association of CD4 gene polymorphism with vitiligo disorder in Iranian population. European journal of Human Genetics 12: suppl. P0955, 2004